Insulin Signaling and Insulin Resistance
نویسندگان
چکیده
منابع مشابه
Insulin, Insulin Resistance, and Platelet Signaling in Diabetes
I nsulin resistance and the metabolic syndrome are associated with a prothrombotic state that contributes to the pathogenesis and progression of the vascular complications of type 2 diabetes. Development of the disease is also linked to the loss of the direct antiplatelet effect of insulin and platelets obtained from patients with diabetes who are hyperreactive (i.e., demonstrate increased adhe...
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Classical actions of insulin involve increased glucose uptake from the bloodstream and its metabolism in peripheral tissues, the most important and relevant effects for human health. However, nonoxidative and oxidative glucose disposal by activation of glycogen synthase (GS) and mitochondrial pyruvate dehydrogenase (PDH) remain incompletely explained by current models for insulin action. Since ...
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Insulin resistance refers to a decreased capacity of circulating insulin to regulate nutrient metabolism. It is associated with the development of type 2 diabetes--an ever-increasing epidemic of the 21st century. Recent studies reveal that agents that induce insulin resistance exploit phosphorylation-based negative-feedback control mechanisms, otherwise utilized by insulin itself, to uncouple t...
متن کاملMagnesium supplementation enhances insulin sensitivity and decreases insulin resistance in diabetic rats
Objective(s): Diabetes mellitus has been suggested to be the most common metabolic disorder associated with magnesium deficiency. This study aimed to investigate the effects and mechanisms of magnesium supplementation on insulin receptor activity in elderly type 2 diabetes using a rat model and to provide experimental evidence for insulin resistance improvement by magn...
متن کاملInsulin and insulin signaling play a critical role in fat induction of insulin resistance in mouse.
The primary player that induces insulin resistance has not been established. Here, we studied whether or not fat can cause insulin resistance in the presence of insulin deficiency. Our results showed that high-fat diet (HFD) induced insulin resistance in C57BL/6 (B6) mice. The HFD-induced insulin resistance was prevented largely by the streptozotocin (STZ)-induced moderate insulin deficiency. T...
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ژورنال
عنوان ژورنال: Journal of Investigative Medicine
سال: 2013
ISSN: 1081-5589,1708-8267
DOI: 10.2310/jim.0b013e3182746f95